Deciding the Better Dose- A Prospective Randomized Double Blind Study of Two Different Doses of Perineural Dexmedetomidine in Axillary Brachial Block
Vol 3 | Issue 2 | July-December 2022 | Page 83-87 | Sheetal Y Chiplonkar, Jalpa A Kate, Dinesh B Vadranapu, Pratibha Toal
DOI: 10.13107/ijra.2022.v03i02.059
Authors: Sheetal Y Chiplonkar [1], Jalpa A Kate [1], Dinesh B Vadranapu [2], Pratibha Toal [1]
[1] Department of Anaesthesiology, BARC Hospital, Anushaktinagar, Mumbai, Maharashtra, India.
[2] Department of Critical Care, P.D. Hinduja Hospital and Research Centre, Mumbai, Maharashtra, India.
Address of Correspondence
Dr. Jalpa A Kate,
Consultant, Department of Anaesthesiology, BARC Hospital, Anushaktinagar, Mumbai, Maharashtra, India.
E-mail: dr.japs@gmail.com
Abstract
Background: Axillary brachial plexus block is generally regarded as the safest and reliable technique for forearm and hand surgeries. Dexmedetomidine, a potent alpha (α)-2-adrenergic receptor agonist when used as an additive in any peripheral nerve block can improve quality of block and postoperative analgesia, though uncertainity prevails regarding the dose in patients undergoing hand and forearm surgeries.
Methods: In this prospective, randomized, comparative, double blind study, 80 patients were included. Each participant fulfilling the inclusion criteria then received axillary brachial plexus block using 15cc 2% lignocaine with adrenaline (1:200000)and 0.5% bupivacaine 5cc mixed with dexmedetomidine either 0.5 µg /kg (group A) or 1 µg /kg ( group B)in 2cc normal saline. Duration of post-operative analgesia was the primary outcome.
Result: Duration of analgesia was significantly prolonged in group B (493.77±115.62 min) compared to group A (434.62±45.18 min, P <0.01).
Conclusion: Between the two doses of dexmedetomidine, block characteristics and analgesia obtained were better with higher dose (1 µg/kg) but chances of side effects like bradycardia increased. Hence 0.5 µg/kg can be a better dose with improved block characteristics yet negligible side effects.
Keywords: Brachial plexus block, Dexmedetomidine Perineural, Peripheral nerve stimulator, Ultrasonography
References
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| How to Cite this Article: Chiplonkar SY, Kate JA, Vadranapu DB, Toal P| Deciding the Better Dose- A Prospective Randomized Double Blind Study of Two Different Doses of Perineural Dexmedetomidine in Axillary Brachial Block | International Journal of Regional Anaesthesia | July-December 2022; 3(2): 83-87. |
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Thanks for expressing your ideas on this blog. Furthermore, a delusion regarding the banking companies intentions while talking about foreclosures is that the traditional bank will not take my installments. There is a fair bit of time that this bank requires payments occasionally. If you are far too deep inside the hole, they’re going to commonly require that you pay the particular payment entirely. However, i am not saying that they will have any sort of repayments at all. In the event you and the traditional bank can seem to work anything out, the actual foreclosure method may cease. However, in case you continue to miss out on payments wih the new approach, the foreclosure process can just pick up where it was left off.
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Thanks for discussing your ideas on this blog. Also, a myth regarding the financial institutions intentions any time talking about home foreclosure is that the bank will not take my repayments. There is a specific amount of time that this bank will take payments from time to time. If you are very deep in the hole, they will commonly desire that you pay the particular payment 100 . However, that doesn’t mean that they will not take any sort of payments at all. Should you and the standard bank can find a way to work one thing out, your foreclosure approach may stop. However, should you continue to skip payments underneath the new system, the foreclosed process can just pick up where it was left off.
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