Vol 6 | Issue 1 | January-June 2025 | Page 20-27 | Anju Grewal, Revanth Babu Challa, Jyoti Sharma
DOI: https://doi.org/10.13107/ijra.2025.v06.i01.118
Open Access License: CC BY-NC 4.0
Copyright Statement: Copyright © 2025; The Author(s).
Submitted: 15-01-2025; Reviewed: 08-02-2025; Accepted: 22-04-2025; Published: 10-06-2025
Authors: Anju Grewal [1], Revanth Babu Challa [2], Jyoti Sharma [1]
[1] Department of Anaesthesiology, All India Institute of Medical Sciences, Bathinda, Punjab, India.
[2] Department of Anaesthesiology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Address of Correspondence
Dr. Jyoti Sharma
Associate Professor, Department of Anaesthesiology, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Email- drjyotisharma1014@gmail.com
Abstract
Regional anaesthesia (RA) is thought to potentially affect cancer recurrence and metastasis by reducing the perioperative stress response, supporting immune function, and decreasing the use of opioids and volatile agents. This review examines the mechanistic evidence and clinical results across eight major cancer types. Although RA reliably enhances pain management and perioperative recovery, its impact on cancer outcomes remains uncertain. The most notable reductions in recurrence are observed in bladder and oesophageal cancers, while the effects on breast, colorectal, gastric, and gynaecological cancers are limited. Variability in study methods, confounding variables, and a scarcity of high-quality randomised controlled trials hinder definitive conclusions. Until more solid evidence is available, personalised anaesthetic strategies are essential.
Keywords: Regional Anaesthesia, Cancer Recurrence, Metastasis
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| How to Cite this Article: Grewal A, Challa RB, Sharma J. Regional Anaesthesia for Cancer Surgery and Its Impact on Recurrence and Metastasis: What Is the Evidence? International Journal of Regional Anaesthesia. January-June 2025; 6(1): 20-27. DOI: https://doi.org/10.13107/ijra.2025.v06.i01.118 |
